肿瘤生物治疗是一种既古老又年轻的疗法 ,上溯千余年 ,在中医药中就有“扶正祛邪、软坚散结、以毒攻毒、活血化瘀”等利用中药来治疗癌症的治则。 1 9世纪末 ,西方提出 Coley毒素治疗癌症 ,现代肿瘤免疫治疗概念的建立始于 1 953年 ,动物肿瘤特异性移植抗原的发现——肿瘤免疫 Tumor biotherapy is an old and young therapy that has been used for more than a thousand years. In traditional Chinese medicine, there are treatments for treating cancer using traditional Chinese medicines such as “righting and eliminating evil spirits, dissolving hard tissues, smashing knots, attacking poison with poison, and promoting blood circulation.” At the end of the 9th century, the West proposed Coley’s toxin to treat cancer. The concept of modern cancer immunotherapy began in 1953. The discovery of animal tumor-specific graft antigens - tumor immunity