论文部分内容阅读
目的:调查我院一年内抗菌药所致药品不良反应(adverse drug reaction,ADR)病例,分析ADR发生的患者相关危险因素。方法:回顾性调查2012年4月~2013年3月我院所有使用抗菌药的病例资料,分析抗菌药ADR发生的可能危险因素,并对其进行单因素分析与Logistic多因素回归分析。结果:8 629例住院患者中发生抗菌药ADR共171例,发生率为1.98%。单因素分析结果显示,患者的年龄、用药品种数、住院日、疾病严重程度、过敏史、基础疾病、肝功能、肾功能等因素与抗菌药ADR有相关性(P<0.01);而患者的性别对抗菌药ADR的发生无显著影响(P>0.05)。Logistic多因素回归分析发现,住院日、疾病严重程度、基础疾病、过敏史是抗菌药ADR发生的独立危险因素。结论:抗菌药ADR的发生是多种因素共同作用的结果,临床上选用抗菌药应综合考虑患者个体因素,减少ADR发生,保障用药安全。
Objective: To investigate the adverse drug reaction (ADR) cases caused by antibacterial drugs in our hospital in one year and to analyze the relevant risk factors of patients with ADR. Methods: A retrospective survey of all cases of antibacterials in our hospital from April 2012 to March 2013 was conducted to analyze the possible risk factors for antimicrobial agents ADR. Univariate analysis and logistic regression analysis were performed. Results: There were 171 ADR cases in 8 629 inpatients, the incidence was 1.98%. The result of univariate analysis showed that there was a significant correlation between ADR and antibiotics (P <0.01), such as patient’s age, number of drugs used, length of hospital stay, severity of disease, history of allergy, underlying diseases, liver function, renal function, Sex had no significant effect on the occurrence of ADR (P> 0.05). Logistic multivariate regression analysis found that hospital stay, severity of disease, underlying disease, and history of allergy were independent risk factors for antimicrobial ADR. Conclusion: The occurrence of antimicrobial agents ADR is a result of many factors, the clinical use of antimicrobial agents should take individual patients into account, reduce the occurrence of ADR, to ensure drug safety.