有研究发现氯氮平对体细胞有诱变效应。为进一步评价其对生殖细胞的诱变性，本文应用人精子染色体离体测试系统研究氯氮平对人精子染色体的影响，结果发现氯氮平浓度分别为２００、４００、８００ｎｇ／ｍｌ时，染色体结构畸变精子率和断裂均数与空白对照组比较均无显著性差异，提示氯氮平在该测试系统中对人精子染色体可能无损伤作用。 Studies have found that clozapine has a mutagenic effect on somatic cells. In order to further evaluate its mutagenicity on germ cells, the human sperm chromatin in vitro test system was used to study the effect of clozapine on human sperm chromosomes. When clozapine concentrations were 200,400 and 800 ng / ml respectively, chromosomes There were no significant differences in the structural aberration rate of spermatozoa and the number of fracture compared with the blank control group, suggesting that clozapine may have no damage to the human sperm chromosome in the test system.