作者以5％的牛磺胆酸钠(Na-Tc)注入大鼠胆胰导管内引起急性出血坏死性胰腺炎。光镜和电镜观察结果显示:注入Na-Tc后10分钟到1小时,胰腺小叶出现细胞膜性结构溶解的灶性坏死,血管少许破坏和轻度出血;注入Na-Tc后3到 6小时,胰腺多个小叶成片坏死,血管溶解和重度出血。坏死前的胰腺细胞内出现大量含有酶原颗粒等细胞器的自噬泡。 The authors injected 5% sodium taurocholate (Na-Tc) into the pancreatic duct of the pancreas in rats causing acute hemorrhagic necrotizing pancreatitis. Light microscopy and electron microscopy showed that: 10 minutes to 1 hour after the Na-Tc injection, there were focal necrosis of the membranous membrane structure in the pancreatic lobules, a little destruction of the blood vessels and slight hemorrhage; 3 to 6 hours after the Na-Tc injection, Multiple leaflets become necrosis, blood vessels dissolve and severe bleeding. A large number of autophagic vacuoles containing organelles such as zymogen granules appear in the pre-necrotic pancreatic cells.