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本实验以结扎家兔冠状动脉左室支６０ｍｉｎ剪开结扎线造成心肌缺血再灌注模型，采用放免方法测定血浆中ＴＸＢ２和６－Ｋｅｔｏ－ＰＧＦ（１ａ）含量，并观察丹参对其影响。结果表明：对照组随心肌缺血再灌注时间的延长ＴＸＢ２在１０ｍｉｎ和３０ｍｉｎ时显著增多（Ｐ＜０．０１，Ｐ＜０．０５），６－Ｋｅｔｏ－ＰＧＦ（１ａ）／ＴＸＢ２值在１０ｍｉｎ时下降（Ｐ＜０．０５），心肌超微结构发生不可逆损伤。丹参保护组ＴＸＢ（１ａ）降低（Ｐ＜０．０５，Ｐ＜０．０１），６－Ｋｅｔｏ－ＰＧＦ（１ａ）／ＴＸＢ２值增加，心肌损伤减轻。说明丹参能减少血小板激活，微循环得以改善，致使心肌结构损伤减轻，保护了心脏功能。
In this experiment, the left ventricular branch of rabbits was ligated for 60 min to cut the ligature to create a model of myocardial ischemia and reperfusion. The levels of TXB2 and 6-Keto-PGF(1a) in plasma were determined by radioimmunoassay, and the effects of Salvia miltiorrhiza were observed. The results showed that TXB2 increased significantly at 10 min and 30 min (P<0.01, P<0.05), and 6-Keto-PGF(1a)/TXB2 reached 10 min with the prolongation of myocardial ischemia-reperfusion time in the control group. Decreased (P<0.05), irreversible damage to myocardial ultrastructure. TXB (1a) decreased in the Salvia miltiorrhiza group (P<0.05, P<0.01), 6-Keto-PGF (1a)/TXB2 increased, and myocardial injury was reduced. It shows that Salvia miltiorrhiza can reduce platelet activation, microcirculation can be improved, myocardial structural damage can be reduced, and heart function can be protected.