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Sutherland和Rall等于1957～1958年在研究肾上腺素和高血糖素引起肝制备释放葡萄糖的作用原理中,首先发现环磷腺苷(cAMP),这些激素能促进cAMP由三磷酸腺苷(ATP)的合成,催化这一反应的酶是腺苷酸环化酶(Adenylate cyclase)。同时发现,在组织浸出液中含有一种环核苷酸磷酸二酯酶(下简称磷酸二酯酶),它能使cAMP水解成5′腺嘌呤核苷酸(5′AMP)而失活。最近证明,各种组织中含有不同的磷酸二酯酶,并对cAMP具有不等程度的亲和力和特异性。激素-受体相互作用的结果是激活腺苷酸环化酶,使ATP转变为cAMP和无机焦
Sutherland and Rall, et al., 1957-1958, studied the action of epinephrine and glucagon on liver production and release of glucose. First, cAMP was found. These hormones promote the synthesis of cAMP from adenosine triphosphate (ATP) The enzyme for this reaction is Adenylate cyclase. Also found in the tissue leachate contains a cyclic nucleotide phosphodiesterase (phosphodiesterase), which can make cAMP hydrolysis 5 ’adenine nucleotide (5’AMP) inactivation. Recently it has been demonstrated that various tissues contain different phosphodiesterases and have varying degrees of affinity and specificity for cAMP. As a result of the hormone-receptor interaction, adenylate cyclase is activated, converting ATP to cAMP and inorganic coke