论文部分内容阅读
用日本血吸虫虫卵注入肺内同步产生肉芽肿的小鼠肺模型进行研究。发现新鲜虫卵注入未致敏小鼠肺内,3.5d即出现细胞反应,28d达高峰,淋巴细胞和巨噬细胞是早期的主要成分。虫卵内抗原(SEA)于注射后第1d最高,随即逐渐下降,卵周抗原3.5d开始逐渐增高,28d达到高峰,其后逐渐减少,未测到抗-SEA抗体。以抗原消耗的虫卵注入致敏小鼠,至第35d实验结束时未见明显肉芽肿形成。结果表明新鲜虫卵能对未致敏小鼠诱发肉芽肿形成;日本血吸虫虫卵肉芽肿形成的机制与曼氏血吸虫者相似,也是虫卵抗原(SEA)诱发的细胞免疫为主的超敏反应。
The lung model of mouse with simultaneous granulomatosis injected with Schistosoma japonicum eggs into the lungs was studied. It was found that fresh eggs were injected into the lungs of non-sensitized mice. After 3.5 days, cellular reaction occurred. The peak reached the peak on 28th day. Lymphocytes and macrophages were the main components in early stage. Egg ova antigen (SEA) in the first day after injection, the highest, then gradually decreased, ovalbumin antigen began to increase 3.5d, reached a peak on 28d, then gradually decreased, did not detect anti-SEA antibodies. The antigen-depleted eggs were injected into sensitized mice and no obvious granuloma formation was observed at the end of the 35th day. The results showed that fresh eggs could induce granuloma formation in non-sensitized mice. The mechanism of egg granuloma formation in Schistosoma japonicum was similar to that of Schistosoma mansoni, but also hypersensitivity to cellular immunity induced by egg antigen (SEA) .