18 8 6年即已得到哒嗪衍生物 ,1895年首次制得哒嗪。但哒嗪化学发展缓缦 ,因自然界中未发现含哒嗪环的化合物。直至近几十年发现不少哒嗪的衍生物具有较强的生理作用 ,哒嗪化学才比较迅速的发展起来。近年来对哒嗪酮类化合物的研究已成为一个重要的领域。哒嗪酮的化学和生物化 Pyridazine derivatives have been obtained in 1886 and pyridazine was first obtained in 1895. But pyridazine chemical slow development, because in nature no pyridazine ring containing compounds found. Until a few decades found that many pyridazine derivatives have a strong physiological role, pyridazine chemistry developed more rapidly. In recent years, the study of pyridazinones has become an important area. Chemical and biological pyridazinone