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目的:探讨呼吸道合胞病毒肺炎不同治疗前后潮气肺功能的变化。方法:用潮气肺功能法检测天津儿童医院呼吸内科2006年12月~2009年12月收治的126例呼吸道合胞病毒肺炎患儿治疗前后的潮气肺功能指标,同时对20例无呼吸道症状的同年龄组婴幼儿进行肺功能检测。结果:呼吸道合胞病毒肺炎急性期与缓解期呼吸频率(RR)、反映小气道功能的指标达峰时间比(TPTEF/TE)、达峰容积比(VPTEF/VE)检测差异有统计学意义(P<0.05);126例呼吸道合胞病毒肺炎患儿急性期和20例正常对照组相比TPTEF/TE、VPTEF/VE差异有统计学意义(P<0.05),其缓解期与对照组相比RR差异无统计学意义(P>0.05),TPTEF/TE、VPTEF/VE差异有统计学意义(P<0.05)。治疗组与未治组比较缓解期TPTEF/TE、VPTEF/VE差异有统计学意义(P<0.05)。孟鲁司特钠组与布地奈德组比较缓解期TPTEF/TE、VPTEF/VE差异无统计学意义。结论:TPTEF/TE、VPTEF/VE是检测小气道功能的敏感指标,在呼吸道合胞病毒肺炎的缓解期和正常对照组相比仍有差异,治疗组与未治组比较缓解期TPTEF/TE、VPTEF/VE差异有统计学意义,应用孟鲁司特钠和布地奈德治疗均能达到一定疗效。
Objective: To investigate the changes of tidal lung function before and after respiratory syncytial virus pneumonia. Methods: The tidal lung function of 126 children with respiratory syncytial virus pneumonia treated in Department of Respiratory Medicine, Tianjin Children’s Hospital from December 2006 to December 2009 were detected by tidal oxygen test. At the same time, 20 patients with no respiratory symptoms Age group infants and young children for lung function tests. Results: Respiratory syncytial virus pneumonia in acute and remission respiratory rate (RR), reflect the small airway function index peak time ratio (TPTEF / TE), the peak volume ratio (VPTEF / VE) test was statistically significant ( P <0.05). There were significant differences in TPTEF / TE and VPTEF / VE between 126 children with respiratory syncytial virus pneumonia and 20 normal controls (P <0.05), and the remission period compared with the control group There was no significant difference in RR between the two groups (P> 0.05). There was significant difference between TPTEF / TE and VPTEF / VE (P <0.05). The difference between TPTEF / TE and VPTEF / VE in treatment group and control group was statistically significant (P <0.05). There was no significant difference in TPTEF / TE and VPTEF / VE between montelukast sodium group and budesonide group. Conclusion: TPTEF / TE and VPTEF / VE are sensitive indicators for detecting small airway function, and there are still differences between the control group and the remission stage of respiratory syncytial virus pneumonia. TPTEF / TE, VPTEF / VE difference was statistically significant, the application of montelukast sodium and budesonide treatment can achieve a certain effect.