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目的观察辛伐他汀对舒张性心力衰竭(DHF)的疗效。方法将62例DHF患者随机分为对照组和辛伐他汀组,在治疗前和随访24个月后检测左室质量指数(LVMI)、左房容积指数(LAVI),血浆N末端脑利钠肽(NT-proBNP)及高敏C反应蛋白(hs-CRP)水平,评价NHYA心功能,测定6min步行距离。结果与对照组治疗后相比,辛伐他汀组NYHA心功能分级下降,6min步行距离延长,NT-proBNP及hs-CRP水平下降,LVMI值及LAVI值降低。结论辛伐他汀通过抑制心脏重构、减轻炎症反应从而对DHF患者有益。
Objective To observe the effect of simvastatin on diastolic heart failure (DHF). Methods Sixty-two patients with DHF were randomly divided into control group and simvastatin group. Before treatment and 24 months after follow-up, the left ventricular mass index (LVMI), left atrium volume index (LAVI), plasma N-terminal brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) were measured. Heart function of NHYA was evaluated. Results Compared with the control group, the cardiac function of NYHA in the simvastatin group was decreased, the walking distance was longer in 6 minutes, the levels of NT-proBNP and hs-CRP were decreased, and the LVMI and LAVI were decreased. Conclusion Simvastatin can benefit DHF patients by inhibiting cardiac remodeling and reducing inflammation.