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目的 :肥胖和乳腺癌密切相关,但其与腋窝淋巴结状态的关系尚不清楚。本文探讨了肥胖与乳腺癌患者腋窝淋巴结状态的相关性。方法:入组306例乳腺癌患者,根据体质指数(body mass index,BMI)分组,回顾性分析患者BMI与肿瘤病理特征,尤其与腋窝淋巴结状态之间的关系。结果:患者平均年龄48岁(范围21~81岁),平均BMI 25.1,在确诊乳腺癌时54.4%(n=166)的患者BMI正常,45.6%(n=140)的患者BMI≥25。入组患者中,59.6%无腋窝淋巴结转移,40.4%有腋窝淋巴结转移。肥胖组(BMI≥25)腋窝淋巴结切除数量大于正常体重组(BMI<25.0),分别为(20.4±11.4)个和(18.1±10.5)个,差异有统计学意义(P<0.01)。腋窝淋巴结转移的数量在正常体重组、肥胖组分别为(3.15±6.1)、(3.7±6.4)个(P>0.05)。正常体重组中有、无淋巴结转移的患者比例分别是39.2%和60.8%;肥胖组中分别为41.4%和58.6%(P>0.05),有、无淋巴结转移与BMI没有相关性。结论:肥胖乳腺癌患者中切除的腋窝淋巴结数量较正常体重者多,但是发生淋巴结转移的患者比例、淋巴结转移数量与BMI之间均没有相关性。
OBJECTIVE: Obesity is closely related to breast cancer, but the relationship between obesity and axillary lymph node status is unclear. This article explores the correlation between obesity and axillary lymph node status in patients with breast cancer. METHODS: A total of 306 patients with breast cancer were enrolled. According to the body mass index (BMI) group, the relationship between BMI and tumor pathological features, especially the status of axillary lymph nodes, was analyzed retrospectively. RESULTS: The average age of patients was 48 years (range, 21-81 years) with an average BMI of 25.1. BMI was normal in 54.4% (n = 166) of those diagnosed with breast cancer and BMI was ≥25 in 45.6% (n = 140). Among the patients enrolled, 59.6% had no axillary lymph node metastasis and 40.4% had axillary lymph node metastasis. The number of resected axillary lymph nodes in obesity group (BMI≥25) was larger than that in normal body weight group (BMI <25.0), which were (20.4 ± 11.4) and (18.1 ± 10.5) respectively, with statistical significance (P <0.01). The number of axillary lymph node metastasis in normal weight group and obesity group were (3.15 ± 6.1) and (3.7 ± 6.4), respectively (P> 0.05). There were 39.2% and 60.8% of the patients in the normal weight group with no lymph node metastasis, 41.4% and 58.6% respectively in the obesity group (P> 0.05). No lymph node metastasis was associated with BMI. Conclusion: The number of excised axillary lymph nodes in patients with obese breast cancer is more than normal, but there is no correlation between the proportion of patients with lymph node metastasis and the number of lymph node metastasis and BMI.