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脑缺血是许多脑血管疾病的共同特征,急性短暂脑缺血也是许多脑血管疾病的先兆。本文研究证明,体感诱发电位(SEP) 的时频分布对缺血脑损伤十分敏感,与缺血性脑血管疾病有密切关系。本文建立了SD 大鼠局灶性缺血脑损伤实验模型,在用一种高分辨率的时频分析方法- 离散Gabor 谱(DGS) 分析SEP的基础上,对局灶性缺血脑损伤进行了研究,发现在局灶性缺血早期,损伤区域与非损伤区域SEP的时频特征即具有明显的不同,可以区分出缺血损伤区域与非损伤区域。时频分析的结果与我们对同一实验对象的热休克蛋白(HSP)表达分析结果相一致。文中定义了能量中心(COP) 和能量重心( WCOP) 。本文的研究结果有可能为局灶性缺血脑损伤的无创诊断找到一种临床实用的定量指标
Cerebral ischemia is a common feature of many cerebrovascular diseases and acute transient cerebral ischemia is also a precursor to many cerebrovascular diseases. This study shows that the time-frequency distribution of somatosensory evoked potential (SEP) is very sensitive to ischemic brain damage and is closely related to ischemic cerebrovascular disease. In this paper, an experimental model of focal ischemic brain damage in SD rats was established. Based on the high-resolution time-frequency analysis of discrete Gabor spectra (DGS) for the analysis of SEP, focal cerebral ischemic injury The study found that in the early stage of focal ischemia, the time-frequency characteristics of SEP in the injured and non-injured areas are obviously different, and the ischemic and non-injured areas can be distinguished. The results of the time-frequency analysis are consistent with our results of heat shock protein (HSP) analysis on the same subject. The paper defines the energy center (COP) and energy center of gravity (WCOP). The results of this study may find a clinical and practical quantitative index for noninvasive diagnosis of focal ischemic brain injury