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目的了解周口市乙型病毒性肝炎流行现状及其变化趋势,为制定乙肝综合预防控制策略提供依据。方法采用多阶段分层整群随机抽样方法,对周口市10个县1~18岁2 449人进行乙肝血清流行病学调查,用酶联免疫吸附法(ELISA)法检测乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗-HBs)。结果周口市人群HBsAg、抗-HBs阳性率分别是2.29%和81.18%,HBsAg阳性率与1999年相比明显下降。结论接种乙肝疫苗是控制人群HBV感染的有效措施,能提高抗-HBs阳性率,降低HBsAg携带率,提高人群对HBV的免疫保护能力。
Objective To understand the prevalence and trend of hepatitis B virus in Zhoukou City and provide evidence for the development of a comprehensive prevention and control strategy for hepatitis B virus. Methods The multistage stratified cluster random sampling method was used to investigate the serogroup HBV seropositivity of 2 449 people aged from 1 to 18 in 10 counties in Zhoukou City, and the detection of hepatitis B virus surface antigen (HBsAg) by enzyme-linked immunosorbent assay (ELISA) ), Hepatitis B virus surface antibodies (anti-HBs). Results The positive rates of HBsAg and anti-HBs in Zhoukou were 2.29% and 81.18% respectively, and the positive rate of HBsAg was significantly lower than that in 1999. Conclusion Hepatitis B vaccination is an effective measure to control HBV infection in the population. It can increase the positive rate of anti-HBs, reduce the carrier rate of HBsAg and enhance the population’s immunity protection ability to HBV.