论文部分内容阅读
基于手性辅剂诱导的手性胺类药物的不对称合成一直受到研究人员的广泛关注,叔丁基亚磺酰胺是近年发展起来的一种新型手性辅剂,本文综述其近几年在手性胺类药物合成中的应用情况,这对于利用叔丁基亚磺酰胺辅助诱导合成手性胺类化合物具有重要意义,验证了手性辅剂在手性药物合成中的重要作用,为进一步开发新型手性辅剂以及在不对称合成中的应用提供参考。
Asymmetric synthesis of chiral amines induced by chiral auxiliaries has drawn much attention from researchers. Tertbutylsulfenamide is a new type of chiral auxiliary developed in recent years. In this paper, Chiral amine drugs in the synthesis of the application, which for the use of tert-butyl sulfenamide-assisted synthesis of chiral amine compounds has important significance to verify the chiral auxiliaries in the synthesis of chiral drugs play an important role in further Development of new chiral auxiliaries and the application in asymmetric synthesis.