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目的:探寻卵巢浆液性交界性肿瘤(SBOT)中clusterin、bcl-2、K-ras及S100A4的表达特点及变化规律,并与相应的良、恶性肿瘤比较,为诊断及鉴别诊断SBOT提供更有效的辅助指标。方法:免疫组化法分析30例SBOT中S100A4、bcl-2、clusterin、K-ras的表达及它们的相关性,并以囊腺瘤和囊腺癌各30例为对照。结果:S100A4、clus-terin、K-ras在浆液性肿瘤的表达随着恶性程度增高呈增加趋势,bcl-2则相反。有腹水患者clusterin阳性率明显高于无腹水者(P=0.0235);有腹膜种植的患者S100A4阳性率明显高于无腹膜种植者(P=0.0242)。且两者表达呈正相关。结论:S100A4高表达往往提示肿瘤的恶性程度高。clusterin与S100A4结合有可能成为能预测卵巢浆液性肿瘤病情发展及指导临床治疗的有价值标记物。
Objective: To investigate the expression and change of clusterin, bcl-2, K-ras and S100A4 in ovarian serous borderline tumors (SBOT), and to compare with corresponding benign and malignant tumors to provide more effective diagnosis and differential diagnosis of SBOT Aid indicators. Methods: The expressions of S100A4, bcl-2, clusterin and K-ras in 30 cases of SBOT were analyzed by immunohistochemistry and their correlations were analyzed. The control group included 30 cases of cystadenoma and cystadenocarcinoma. Results: The expression of S100A4, clus-terin and K-ras in serous tumors increased with the increase of malignant degree, while bcl-2 was the opposite. The positive rate of clusterin in patients with ascites was significantly higher than those without ascites (P = 0.0235). The positive rate of S100A4 in patients with peritoneal implantation was significantly higher than those without peritoneal implantation (P = 0.0242). And the two expressions were positively correlated. Conclusion: The high expression of S100A4 often suggests that the malignancy of the tumor is high. The combination of clusterin and S100A4 may be a valuable marker for predicting the progression of ovarian serous tumors and for guiding clinical treatment.