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目的观察关节镜下滑膜切除治疗膝关节类风湿性滑膜炎患者血清中TNF-α、IL-1和IL-6的水平变化。方法 30例膝关节类风湿性滑膜炎患者行关节镜下滑膜切除术,检测治疗前后外周血TNF-α、IL-1及IL-6的水平变化,并根据Lysholm评分进行膝关节功能评估。结果 30例患者均获得4周~6个月随访,未出现感染、下肢静脉血栓等并发症。与治疗前相比,治疗后TNF-α、IL-1和IL-6水平降低,而膝关节Lyshlom评分增加(P<0.05)。结论关节镜下滑膜切除治疗膝关节类风湿性滑膜炎能明显降低TNF-α、IL-1及IL-6水平,改善患者膝关节功能。
Objective To observe the changes of serum levels of TNF-α, IL-1 and IL-6 in patients with knee joint rheumatoid synovitis treated by arthroscopy synovectomy. Methods Thirty patients with knee joint rheumatoid synovitis underwent arthroscopic synovectomy. The levels of TNF-α, IL-1 and IL-6 in peripheral blood were measured before and after treatment. The knee function was evaluated according to Lysholm score. Results All the 30 patients were followed up for 4 weeks to 6 months without complications such as infection and venous thrombosis of the lower extremities. After treatment, the levels of TNF-α, IL-1 and IL-6 decreased, while the Lyshlom score increased (P <0.05). Conclusion Arthroscopic synovectomy for the treatment of knee joint rheumatoid synovitis can significantly reduce the levels of TNF-α, IL-1 and IL-6 and improve the knee joint function.