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为了保证药剂质量,我们对临床上常用的四环素糖浆、红霉素滴眼液、新霉素滴眼液和庆大霉素滴眼液的稳定性作了考察。各制剂的效价测定,按《中国药典1977年版》(试行稿)规定,用二剂量法。简报如下。一、四环素糖浆四环素糖浆选择了3种处方,配制后,在25℃贮存条件下,分别于当天、第4、7和10天测定其生物效价,高剂量40单位/ml,低剂量20单位/ml。由于检品含糖,所以标准品溶液中也加相应量的蔗糖。处方 A:四环素糖粉 2.5g(相当于25万单位)苯甲酸钠 0.2g枸橼酸 0.2g
In order to ensure the quality of pharmaceuticals, we examined the stability of tetracycline syrup, erythromycin eye drops, neomycin eye drops and gentamicin eye drops commonly used clinically. Determination of the potency of each preparation, according to “Chinese Pharmacopoeia 1977 edition” (draft) provisions, with two doses. Briefing is as follows. A tetracycline syrup Tetracycline syrup selected three kinds of prescription, after the preparation, at 25 ℃ storage conditions, respectively, the same day, 4, 7 and 10 days to determine its biological potency, high dose of 40 units / ml, low dose of 20 units / ml. As seized goods sugars, so the standard solution also add the appropriate amount of sucrose. Prescription A: Tetracycline sugar powder 2.5g (equivalent to 250,000 units) Sodium benzoate 0.2g Citric acid 0.2g