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采用大鼠子宫内膜异位症动物模型，观察ＬＨＲＨ类似物丙氨瑞林缓释微球注射剂（ＬＨＲＨＡｍｓ）对异位内膜的抑制作用及对垂体促黄体细胞（ＬＨ细胞）的形态学影响。结果显示，ＬＨＲＨＡｍｓ剂量为１００μｇ／ｋｇ／ｄ时，对大鼠异位内膜有明显抑制，可达“药物性去卵巢”作用，使大鼠垂体ＬＨ细胞呈现特征性改变：胞体明显变小，呈明显的不规则状，内含颗粒减少，胞质内液泡消失。当剂量达到２００μｇ／ｋｇ／ｄ时，子宫内膜抑制率及垂体ＬＨ细胞形态特征均无相应改变，可能是药物达最大作用后，下丘脑垂体卵巢轴对药物的反应性下降或消失所致。
The animal model of rat endometriosis was used to observe the inhibitory effect of LHRH analogue sustained release microspheres injection (LHRHAms) on the ectopic endometrium and the morphological changes of LH cells . The results showed that the LHRHAms dose of 100μg / kg / d, the rat ectopic endometrium was significantly inhibited, up to the “drug ovariectomy”, so that the rat pituitary LH cells showed a characteristic change: significantly reduced cell body, Obvious irregular shape, containing particles reduced cytoplasmic vacuoles disappear. When the dose reached 200μg / kg / d, the inhibitory rate of endometrium and the morphology of pituitary LH cells were not changed correspondingly, which may be caused by the decrease or disappearance of the reactivity of hypothalamic pituitary ovary axis to the drug after maximal effect.