近期研究发现，细胞质内Ｃａ￣（２＋）浓度增加、ｃＡＭＰ累积、蛋白激酶激活、酪氨酸蛋白激酶激活和神经酰胺产生等一系列信号，在多种模型中调节细胞凋亡。这些信号在不同细胞中的调节作用不同，启动或阻碍细胞凋亡。本文对这些现象进行了讨论，并对一系列信号传递系统在多细胞应答中的作用机制提出解释。 Recent studies have found that a series of signals such as increased Ca 2+ concentration, accumulation of cAMP, activation of protein kinases, activation of tyrosine protein kinases and ceramide production in the cytoplasm regulate apoptosis in various models. These signals regulate differently in different cells, triggering or hindering apoptosis. This article discusses these phenomena and explains the mechanism of action of a series of signaling systems in multicellular responses.