精确限定通气压力以维持某一最小有效肺容量的通气方式,会导致CO_2的潴留,但是对肺泡压的适当限制可以提高生存率,因为通气压力和潮气量过大可直接造成或加重肺损伤。ARDS病人必须避免使用高于正常肺组织的跨肺泡压,同时采用足够的PEEP,调整平均气道开口压,延长呼吸周期以减轻或消除机械通气对肺的损伤作用。 Ventilation that precisely limits the ventilation pressure to maintain a minimal effective lung volume results in CO2 retention, but proper restriction of alveolar pressure increases survival because excessive ventilation pressure and tidal volume can directly contribute to or worsen lung injury. ARDS patients must avoid the use of higher than normal lung tissue alveolar pressure, while using enough PEEP, adjust the average airway pressure, prolong the respiratory cycle to reduce or eliminate the role of mechanical ventilation on the lung injury.