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美西律结构类似利多卡因,具有抗惊厥和局部麻醉作用,列为Ⅰb类抗心律失常药。据证明,本品对慢性室性心律失常的疗效类似普鲁卡因胺、奎尼丁或丙吡胺。 100例频发性、高级别室性心律失常患者,Holter监测48小时,室早每小时348±411次,成对室早每小时352±480对,非阵发性室速每24小时39±107阵。曾用过奎尼丁、普鲁卡因胺、丙吡胺、普萘洛尔或氯卡胺,因不能耐受,或治疗量无效或禁忌而停药。美西律,静滴负荷量400mg(每分钟10mg),继以维持量每分钟1mg(0.5～1.5mg)共24～48小时;口服起始量150～200mg每6～8小时1次,极量300mg每6小时1次。随访17个月(2日至84个月)。随访期有39%病例需联合用药;美西律维持量每日平均782±189mg。
The mexiletine structure is similar to that of lidocaine, which has anticonvulsant and local anesthetic effects and is classified as Class Ib anti-arrhythmic drug. It has been proven that the product of the efficacy of chronic ventricular arrhythmias similar to procainamide, quinidine or disopyramide. 100 patients with frequent, high-grade ventricular arrhythmias were monitored by Holter for 48 hours, 348 ± 411 premature echocardiography, 352 ± 480 premature echocardiography for paired patients, 39 ± 24 hours per non-paroxysmal VT 107 array. Quinidine, procainamide, disopyramide, propranolol or clofazadine have been used and discontinued due to intolerability, or ineffective or contraindicated treatment. Meclizine, intravenous infusion of 400mg (10mg per minute), followed by the maintenance dose of 1mg per minute (0.5 ~ 1.5mg) for a total of 24 to 48 hours; oral starting amount of 150 ~ 200mg every 6 to 8 hours once Quantity 300mg every 6 hours 1 time. Followed up for 17 months (2 days to 84 months). Follow-up period 39% of the cases need combination therapy; the average daily maintenance of mexiletine 782 ± 189mg.