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目的:研究布洛芬巴布剂在兔体内药动学。方法:用HPLC法测定兔分别给予布洛芬巴布剂和混悬液后不同时间点血浆中布洛芬的浓度,计算药动学参数和相对生物利用度,并对2种制剂的主要药动学参数分别进行单、双侧t检验。结果:布洛芬混悬液和自制巴布剂贴后的药动学过程均符合一房室一级吸收模型,2种制剂的主要药动学参数Ka、Ket、1/2(Ka)t、1/2(Ke)t、peak均有显著性差异(P<0.05),巴布剂具有缓释作用,当巴布剂给药量为口服液的2倍时可达到有效血药浓度,峰浓度与口服液的峰浓度差异无显著性,自制贴剂的相对生物利用度为(94.1±6.0)%。结论:与参比混悬剂相比,自主开发的巴布剂药动学参数发生了明显改变,且具有缓释作用。
Objective: To study the pharmacokinetics of ibuprofen poultice in rabbits. Methods: The concentrations of ibuprofen in plasma were determined by HPLC after being given ibuprofen poultice and suspension respectively at different time points. The pharmacokinetic parameters and relative bioavailability were calculated. The main drugs Dynamic parameters were single and double t test. Results: The pharmacokinetics of ibuprofen suspension and self-made cataplasm were in accordance with the first-compartment absorption model. The main pharmacokinetic parameters Ka, Ket, 1/2 (Ka) t , 1/2 (Ke) t, peak (P <0.05). The cataplasm has a sustained release effect. When the cataplasm dose is twice that of the oral solution, the effective blood concentration can be reached, There was no significant difference between the peak concentration and the peak concentration of oral solution. The relative bioavailability of homemade patch was (94.1 ± 6.0)%. CONCLUSION: Compared with the reference suspension, the pharmacokinetic parameters of the self-developed cataplasm have changed significantly, and the drug has a sustained release effect.