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通过随机分组对比观察环磷酰胺冲击和累积给药两种方法治疗原发性肾病综合征 ,结果显示冲击治疗组有效率高于累积给药组 ;达到完全缓解所需的时间及环磷酰胺剂量低于累积治疗组 ;在显著缓解和完全缓解的病人中 ,尿蛋白减少一半所需的时间和环磷酰胺剂量也低于累积治疗组 ,同时冲击治疗组病人肾功能恢复也优于累积治疗组 ,而且冲击治疗组副作用低于累积组 ,提示环磷酰胺冲击治疗能更快更有效地降低尿蛋白 ,并有利于肾功能恢复 ,而且副作用少
Through randomized comparison and observation of cyclophosphamide and cumulative administration of two methods of treatment of primary nephrotic syndrome, the results showed that the impact of the treatment group was higher than the cumulative administration group; to complete the time required for complete remission and cyclophosphamide dose Lower than the cumulative treatment group; in patients with significant remission and complete remission, urinary protein reduced by half the time required and the dose of cyclophosphamide is also lower than the cumulative treatment group, while the impact of treatment group patients with renal function recovery is also better than the cumulative treatment group , And the side effects of the impact treatment group was lower than that of the cumulative group, suggesting that cyclophosphamide impact treatment can lower urinary protein faster and more effectively and is beneficial for renal function recovery with less side effects