论文部分内容阅读
目的分析影响肝外胆管癌远期疗效的因素,探讨不同的治疗方法对其预后的影响,总结诊治经验。方法对84例肝外胆管癌临床病理资料进行回顾分析,应用SPSS10.0统计软件包进行统计学分析。结果胆管癌患者的总体5年生存率为13.1%。胆管癌根治切除组的1,3,5年生存率分别为76.8%、52.6%和30.5%。根治切除组与姑息手术组、剖腹探查组、非手术组间差异有统计学意义(P<0.01)。Cox多因素分析显示,淋巴结转移、组织学分级、远处转移与胆管癌的预后显著相关。结论肝外胆管癌患者扩大切除范围有望改善预后,但总体疗效有限。早期诊治及综合治疗是改善预后的关键。
Objective To analyze the factors that affect the long-term curative effect of extrahepatic cholangiocarcinoma, to explore the influence of different treatment methods on the prognosis and to summarize the experience of diagnosis and treatment. Methods The clinicopathological data of 84 cases of extrahepatic cholangiocarcinoma were retrospectively analyzed and statistically analyzed by using SPSS10.0 statistical package. Results The overall 5-year survival rate of patients with cholangiocarcinoma was 13.1%. The 1, 3, 5-year survival rates of radical resection of cholangiocarcinoma were 76.8%, 52.6% and 30.5% respectively. The difference between radical resection group and palliative surgery group, laparotomy group and non-surgical group was statistically significant (P <0.01). Cox multivariate analysis showed that lymph node metastasis, histological grade, distant metastasis and prognosis of cholangiocarcinoma were significantly correlated. Conclusion Extended resection of extrahepatic cholangiocarcinoma patients is expected to improve prognosis, but the overall effect is limited. Early diagnosis and treatment and comprehensive treatment is the key to improving prognosis.