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本实验以猪为模型,探讨败血症性休克的主要毒素──内毒素对冠状动脉(冠脉)循环的影响。从静脉输注内毒素,浓度为4ng/ml按每分钟0.3ng/kg持续输入。该剂量内毒素未引起血压下降,也不损害冠脉的自动调节功能,冠脉流量保持恒定。但当冠脉灌注压降至4.67kPa时,内毒素使冠脉流量增加(输注前和后分别为62.5±29.2和89.5±32.7ml/min,P<0.05)。对内毒素增加冠脉流量的可能机理进行了初步探讨。
In this study, pigs as a model to explore the main toxin septic shock ─ ─ endotoxin on the coronary (coronary) cycle. Endotoxin was infused intravenously at a concentration of 4 ng / ml at 0.3 ng / kg per minute. This dose of endotoxin did not cause a drop in blood pressure, nor did it impair the autoregulation of coronary arteries, and coronary flow remained constant. However, when the perfusion pressure dropped to 4.67 kPa, endotoxin increased coronary flow (62.5 ± 29.2 and 89.5 ± 32.7 ml / min before and after infusion, P <0, respectively). 05). The possible mechanism of the increase of coronary flow by endotoxin was discussed.