感染日本血吸虫病的家兔用F30385或呋喃丙胺治疗,剂量分别为50及150毫克/公斤×14天时,无论在结束治疗时或治后4周内,寄居在小肠肠系膜静脉内的血吸虫显著减少或消失,且移行至肝内的两性虫皆退化死亡,但残留在直肠静脉内的虫数则与治前相仿,虫的大小及形态亦无明显变化,若在治疗的第1—2天,于口服F30385或呋喃丙胺前2小时注射6—12毫克/公斤的吐酒石,以促使肠系膜下静脉内的虫体肝移,则不仅可提高减虫率,且可使部分病兔获得治愈。 Schistosoma japonicum-infected rabbits treated with F30385 or furosemide for 50 and 150 mg / kg x 14 days, respectively, showed a significant reduction in schistosomiasis in the small intestinal mesenteric vein either at the end of treatment or within 4 weeks after the treatment Disappeared, and migrate into the liver of the amphipathic degenerative death, but the residual number in the rectum vein is similar with the pre-treatment, the size and shape of the worm has no significant change, if the treatment of 1-2 days in the Two hours before oral administration of F30385 or furosemide, 6-12 mg / kg of toadstool was injected to promote hepatic movement of the parasites in the inferior mesenteric vein, which not only increased the worm reduction rate but also cured some of the rabbits.