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小鼠于感染继发性细粒棘球蚴后用甲苯达唑口服治疗,剂量为12.5～100mg/kg/d×10时囊肿抑制率为49.2～77.5％,用阿苯达唑100～300mg/kg/d×10～14治疗的为61.3～72.1％,而用吡喹酮400mg/kg/d,或800mg/kg/d,2次均服,疗程为10d时则无效,但若给服500mg/kg/d×14,囊肿抑制率为63.4％。药物有效各组的每鼠平均囊数,除个别组外,均较相应对照组的为少。此外,甲苯达唑与吡喹酮合并服用,有一定的增效作用。
Mice were treated with mebendazole orally after infection with Echinococcus granulosus. The inhibition rate of cysts was 49.2-77.5% at dose of 12.5-100 mg / kg / d × 10, and the dose of albendazole 100-300 mg / kg / d × 10 ~ 14 for the treatment of 61.3 ~ 72.1%, and with praziquantel 400mg / kg / d, or 800mg / kg / d, 2 times the average, the treatment is 10d is not effective, but given 500mg / kg / d × 14, the cyst inhibitory rate was 63.4%. The average number of cysts per mouse in each drug-effective group was less than that in the corresponding control groups, except for individual groups. In addition, mebendazole combined with praziquantel, there is a certain synergistic effect.