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经对54个MZ双生对家系和19对DZ者共465人进行的一次血压水平家族性聚集研究发现,血压水平呈显著的家族性聚集,乃遗传与环境共同作用的结果;SBP与DBP的h_B~2分别为0.48和0.56,h_N~2分别为0.32和0.44;体量因子对此聚集无显著作用;对血压水平存在母体效应;血压变异系由一系列累加微效基因与各种环境因素的交替所致,群体血压频数分布呈正态分布曲线,这与多因子遗传模式相一致,此曲线偏高尾端部分构成了部分临床上被诊断为原发性高血压(E-HT)的病人;另一部分E-HT病人可能由主要基因替代所致;在临床上仅根据血压测量不能区分这两类本质不同的E-HT。寻找E-HT的遗传标记乃是在此领域作进一步研究的目的。
A familial aggregation study of 465 individuals with 54 MZ twin pairs and 19 DZs found a significant familial aggregation of blood pressure levels as a result of genetic and environmental interactions; ~ 2 were 0.48 and 0.56 respectively, h_N ~ 2 was 0.32 and 0.44, respectively. There was no significant effect of body mass index on this aggregation. There was a maternal effect on blood pressure. The variation of blood pressure was determined by a series of accumulated micro-effect genes and various environmental factors Alternately, the frequency distribution of the group’s blood pressure showed a normal distribution curve consistent with the multifactorial genetic model, with the tail of the curve forming part of the clinically diagnosed patients with essential hypertension (E-HT) Another part of E-HT patients may be caused by the replacement of the major genes; clinically only based on blood pressure measurement can not distinguish between these two types of essentially different E-HT. Finding genetic markers for E-HT is the goal of further research in this area.