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前列腺素(PGs)是由必需脂肪酸合成的甘碳的氧合脂肪酸。PGs不能在细胞中贮存,但需要时可由一系列酶反应迅速合成,如通过“损伤”、炎症、肿瘤等刺激细胞膜,即可使花生四烯酸转化成PGs。一、合成的PGs类似物及其对胃分泌的影响自发现PGE系是人体基础的和刺激时的胃酸分泌的强抑制剂后,又研究了其对溃疡的作用。然而,天然的PGs可被人体组织中的酶迅速代谢失活,因此寿命短。于是开发了各种PGs类似物,它们可耐受正常酶的代谢,口服有效,并且比天然类似物作用更强。口服微克量的PGE和PGE_2的合成类似物即可抑制组胺、五肽胃泌素和食物刺激
Prostaglandins (PGs) are oxygenated fatty acids of the carbon-carbon synthesized from essential fatty acids. PGs can not be stored in cells but can be rapidly synthesized by a series of enzymatic reactions when needed. Arachidonic acid can be converted into PGs by stimulating cell membranes through “damage”, inflammation, tumors, and the like. Synthetic PGs Analogues and Their Effects on Gastrointestinal Secretion PGE is a potent inhibitor of gastric acid secretion at the basal and stimulatory levels found in humans and its role in ulceration. However, native PGs can be rapidly metabolically inactivated by enzymes in human tissues and therefore have a short lifespan. Thus various PGs analogs have been developed that are tolerant of normal enzyme metabolism, orally effective and more potent than natural analogues. Oral micrograms of synthetic analogs of PGE and PGE 2 inhibit histamine, pentagastrin, and food stimuli