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为探讨中医药防治自然流产的机理 ,以利血平、米非司酮 (RU4 86 )建立病证结合动物流产模型 ,模拟脾虚、黄体不健的状态 ,观察补肾健脾中药复方“助孕 3号方”对该模型流产率的影响 ;并以四君子汤、黄体酮为对照 ,同时设立脾虚流产模型组、脾虚模型组、流产模型组及正常妊娠组 ;以血清孕激素水平、子宫蜕膜孕激素受体 (PR)阳性率及子宫卵巢病理形态学变化为观察指标。结果 :助孕 3号组流产率低于四君子汤组、流产模型组 (P <0 .0 5) ;该组孕激素水平、PR阳性率均比四君子汤组、脾虚流产模型组、流产模型组高 ;并对脾虚大鼠体重的减轻有改善作用。提示 :“助孕 3号方”是通过促进妊娠黄体和合体滋养细胞的分泌功能 ,维持靶细胞受体的含量及改善脾虚证候、提高整体功能而发挥效应。说明其作用是多环节、多层次的。同时表明脾肾并补法优于单纯健脾法 ,补肾药在防治流产方面可能起主导作用
In order to explore the mechanism of traditional Chinese medicine in preventing and treating spontaneous abortion, reserpine and mifepristone (RU4 86) were used to establish disease syndrome and animal abortion models to simulate the state of spleen deficiency and corpus luteum deficiency. No.2 “Affects on the abortion rate of the model; with Sijunzitang and progesterone as controls, a spleen abortion model group, spleen deficiency model group, abortion model group, and normal pregnancy group were established at the same time; serum progesterone levels, uterine peritoneal membrane pregnancy The positive rate of hormone receptor (PR) and the morphological changes of uterine ovary were observed. Results: The miscarriage rate in Zhuyun No. 3 group was lower than Sijunzi Decoction group and abortion model group (P < 0.05); Progesterone level and PR positive rate in this group were all higher than those in Sijunzi Decoction group, Spleen Deficiency abortion model group, and abortion model group. High; and improve the role of reducing body weight of spleen deficiency rats. Tip: ”Zhuyun No.3 Formula" is to promote the secretion of target cell receptors, improve the spleen deficiency syndrome, and improve overall function by promoting the secretion of gestational corpus luteum and syncytiotrophoblast cells. Explain its role is multi-level, multi-level. At the same time, it is shown that spleen and kidney complement method is better than simple spleen method and kidney tonic may play a leading role in prevention and treatment of miscarriage