目的:观察芎桃二乌止痛酊对皮肤的刺激性及过敏性。方法:以实验豚鼠为模型,分别进行皮肤刺激实验和致敏试验,观察芎桃二乌止痛酊对皮肤的刺激作用和致敏作用。结果:皮肤刺激实验中完整皮肤组及破损皮肤组未见红斑和水肿,平均分值为零;皮肤过敏实验中芎桃二乌止痛酊不引起豚鼠过敏反应,致敏率为零。结论:芎桃二乌止痛酊对豚鼠皮肤无刺激、无致敏作用,外用质量安全可控。 Objective: To observe the irritability and allergy to the skin of Wu Tao Zhitong Tincture. Methods: Guinea pigs were used as experimental models to test skin irritation and sensitization respectively. The stimulating effect and sensitization effect of Xion Tao Er Wu Zhitong Tincture on skin were observed. Results: There was no erythema and edema in the complete skin group and the damaged skin group in the skin irritation test. The average score was zero. In the skin allergy test, the peach notoginseng tincture did not cause guinea pig anaphylaxis, and the sensitization rate was zero. Conclusion: Xion Tao Er Wu Zhitong Tincture of guinea pig skin without stimulation, no sensitization, external quality and safety controllable.