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在1项国家自然科学基金项目、2项国家自然科学基金重点项目、3项美国中华医学会基金(CMB)、中国科学院出版基金项目等基金资助下,对药物代谢与反应差异的遗传机制及其规律进行了近20年的系统、深入的研究。 1.查明了多种药物代谢酶在我国多个民族中的基因多态性和活性分布特征,阐明了药物代谢酶活性及药物反应民族差异的遗传机制。
The genetic mechanisms of differences in drug metabolism and response under the support of one National Natural Science Foundation of China, two National Natural Science Foundation of China key projects, three CMB and the Chinese Academy of Sciences publication fund project Law for nearly 20 years of systematic and in-depth study. 1. Identified a variety of drug metabolism enzymes in many ethnic groups in our country gene polymorphism and activity distribution characteristics, clarified the drug metabolism enzyme activity and drug response to the national differences genetic mechanism.