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本文从近代有机化学结构观点出发,结合共轭酸碱的概念,以含氮有机药物分子中氮原子的杂化方式不同为根据,对含氮有机药物的碱性与结构的关系加以分析和讨论。在本文的最后部分,结合临床上所遇到的有关问题,例如对药物酸碱性的判断、如何用pKa或pKb值比较含氮有机药物碱性的强弱、对有关药物化学稳定性的估计以及在药物之间相互作用等方面的应用,均以实例予以重点讨论。
Based on the concept of conjugate acid and alkali and the difference of nitrogen atom hybridization in nitrogen-containing organic drug molecules, the relationship between basicity and structure of nitrogen-containing organic drugs is analyzed and discussed from the viewpoint of modern organic chemical structure. . In the last part of this paper, we combine the clinical problems, such as the judgment of the drug’s acid-base, how to compare the basicity of nitrogen-containing organic drugs by pKa or pKb, and estimate the chemical stability of the drug As well as the application of the interaction between drugs, are given examples to be focused on.