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9只狗受到~(60)Coγ线全身照射1000rad,经同窝骨髓移植,其中7例发生移植物抗宿主病(GVHD简称抗宿主病)。其病变主要发生于皮肤(7只)、口腔粘膜和小肠(各6只)、肝脏(5只)、大肠(4只)等处。指出口腔粘膜病变较为多见,应予重视。抗宿主病的主要病理变化是变性、坏死、溃疡形成(或剥脱)、充血、淋巴细胞浸润等;扫描电镜见浸润的淋巴细胞膜表面缺乏微绒毛。在抗宿主病的病理诊断中,应注意与辐射损伤、药物反应、免疫抑制剂毒性及原有疾患相鉴别。
Nine dogs received whole-body radiation of ~ (60) Co γ-ray irradiation of 1000 rads and were transplanted through the same bone marrow. Seven of them developed graft-versus-host disease (GVHD). The lesions occurred mainly in the skin (7), oral mucosa and small intestine (6 each), liver (5), large intestine (4) and other places. Oral mucosal lesions are more common, should be taken seriously. Anti-host disease is the main pathological changes degeneration, necrosis, ulcer formation (or exfoliation), congestion, lymphocyte infiltration, etc .; scanning electron microscopy see infiltration of lymphocytes membrane surface lack of microvilli. In the pathological diagnosis of anti-host disease, attention should be paid and radiation damage, drug reactions, immunosuppressive agents and the original disease phase identification.