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观察了垂体瘤和小脑幕下肿瘤及脑外伤术后病人尿中表皮生长因子（ＥＧＦ）的变化，尿中糖、Ｎ乙酰β氨基葡萄糖苷酶（ＮＡＧ）、尿酸（Ｕａ）、尿γ谷氨酰转移酶（γＧＴ）的变化，血浆肾素活性（ＰＲＡ）、血管紧张素Ⅰ和Ⅱ（ＡＮＧⅠ和Ⅱ）的变化，以及内生肌酐清除率（Ｃｃｒ）、渗透溶质分子清除率（Ｃｏｓｍ）的变化。结果脑疾患术后尿ＥＧＦ排出量及尿Ｕａ与正常对照组比较明显降低（Ｐ＜００１），Ｃｃｒ与正常对照组比较无显著性差异（Ｐ＞００５），ＰＲＡ、ＡＮＧⅠ、ＡＮＧⅡ、Ｃｏｓｍ及尿中糖、ＮＡＧ、γＧＴ的排出量与正常对照组比较明显升高（Ｐ＜００５或＜００１）。尿ＥＧＦ与尿ＮＡＧ、γＧＴ呈负相关（Ｐ＜００５）。
The changes of epidermal growth factor (EGF), urinary glucose, N-acetylglucosaminidase (NAG), uric acid (Ua) and urinary γ in urine of patients with pituitary tumor and inferior cerebellar tumor and brain trauma were observed. (ΓGT), changes of plasma renin activity (PRA), angiotensin Ⅰ and Ⅱ (ANGⅠand Ⅱ), as well as changes of endogenous creatinine clearance (Ccr), osmotic solute molecular clearance (Cosm) changes. Results The urinary EGF excretion and urine Ua in patients with cerebrovascular disease were significantly lower than those in the normal control group (P <001), but there was no significant difference between Ccr and the normal control group (P> 005), PRA, ANGⅠ, ANGⅡ , Cosm and urine sugar, NAG, γ GT excretion was significantly higher than the normal control group (P <0 05 or <0 01). Urinary EGF and urine NAG, γ GT was negatively correlated (P <0 05).