核小体是染色质的亚单位,它是七十年代细胞生物学的重大发现。1974年Olins & Olins将分离的细胞核经低渗处理,导致核膨胀而染色质丝伸展,经透射电镜观察,发现染色质丝呈串珠状,串珠颗粒直径约100(?),Olins将它们命名为ν小体,后来Chambon将此结构改称为核小体(核体或核粒)。近年来经生物化学 The nucleosome is a chromatin subunit, a major discovery of cell biology in the seventies. In 1974, Olins & Olins isolated the nucleus by hypotonic treatment, leading to nuclear expansion and chromatin filaments stretch, observed by transmission electron microscopy and found that the chromatin filaments beaded, beaded particles about 100 (?), Olins named them ν small body, and later Chambon renamed this structure nucleosomes (nucleosomes or nuclei). In recent years by biochemistry