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乳头瘤病毒(PV)属于乳多空病毒(Papova Virus),是由Shop于1933年发现。此后,人们从羊、牛、马、鹿、狗和人等多种哺乳动物身上分离出了各种动物的PV。已知PV是一种亲上皮性的肿瘤病毒,可引起皮肤疣和粘膜湿疣或乳头瘤。人们观察发现,某些动物的乳头瘤可发展为癌,人体也有类似情况发现。这就引导人们对于HPV的生物学特点及其与癌发生的关系进行进一步研究。一、HPV的生物化学及其分型 PV由DNA和蛋白组成,直径45～55nm。病毒基因由共价闭环的双股超螺旋组成,含大约8000个核苷酸对,由72个衣壳蛋白
Papillomavirus (PV) belongs to Papova Virus and was discovered by Shop in 1933. Since then, people have been isolated from a variety of mammals such as sheep, cattle, horses, deer, dogs and humans. PV is known to be a pro-epithelial oncolytic virus that causes cutaneous warts and genital warts or papillomas. People observed that some animals, papilloma can develop into cancer, the body also found a similar situation. This led to further research on the biological characteristics of HPV and its relationship with carcinogenesis. First, the biochemical HPV and its classification PV from DNA and protein composition, diameter 45 ~ 55nm. The viral gene consists of a covalently closed double-stranded supercoiled helix containing about 8000 nucleotide pairs consisting of 72 capsid proteins