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近年来,手足口病(Hand foot mouth disease,HFMD)在中国多次爆发流行,严重威胁公众健康,尤其是5岁以下的婴幼儿。而肠道病毒71型(Enterovirus 71,EV71)是引起手足口病的主要病原体之一,由于目前还无针对该疾病有效的抗病毒药物,研制疫苗是控制EV71流行最为有效的措施。目前EV71疫苗及相关研究均取得重大突破,本文就近年来关于EV71疫苗研发、动物模型等的研究进展作一综述。
In recent years, Hand foot mouth disease (HFMD) has repeatedly erupted in China, posing a serious threat to public health, especially for infants and children under 5 years of age. Enterovirus 71 (EV71) is one of the major pathogens that cause hand-foot-mouth disease. Since no effective antiviral drug is currently available for the disease, developing a vaccine is the most effective measure to control the EV71 epidemic. The current EV71 vaccine and related research have made major breakthroughs, this article in recent years on EV71 vaccine research and development, animal models are reviewed.