对疟原虫侵入红细胞的机理目前知道得尚少。有人认为在寄生虫进入宿主细胞过程中需在局部破坏表膜成份,寄生虫与宿主细胞表膜接触时有一个溶解蛋白的过程,某些蛋白酶抑制剂可以抑制红细胞受感染。作者研究了蛋白酶抑制剂抑蛋白酶醛肽和抑胰凝乳蛋白霉素对体外培养恶性疟原虫的作用,观察到抑蛋白酶醛肽和抑胰凝乳蛋白霉素能抑制恶性疟原虫感染人红细胞。如果红细胞预先用胰凝乳蛋白酶处理,则抑胰 The mechanism of malaria parasite invasion of red blood cells is still less known. Some people think that in the process of parasites into the host cells in the destruction of epidermal tissue components, parasite and host cell membrane in contact with a dissolution of protein process, some of the protease inhibitors can inhibit the infection of red blood cells. The authors studied the effects of the protease inhibitors aprotinin and trypsin on cultured P. falciparum in vitro. It was observed that aprotinin and piroxicam inhibited the infection of human erythrocytes with P. falciparum. If erythrocytes are pretreated with chymotrypsin, then trypanosoma inhibition