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目的 研究胃癌组织中组织蛋白酶D(CD)的表达并探讨CD与胃癌生物学行为的相关性。方法 运用S -P免疫组化方法检测 5 0例胃癌组织CD的表达 ,并分析与胃癌临床因素、临床病理分期间的关系。结果 CD阳性表达率 72 % (36 / 5 0 ) ,CD阳性表达率在低分化组 (2 3/ 2 6 )明显高于分化组 (13/ 2 4) ;浆膜侵犯组 (2 0 / 2 2 )明显高于未侵犯组 (16 / 2 8) ;淋巴结转移阳性组 (2 1/ 2 4)明显高于淋巴结转移阴性组 (15 / 2 6 ) ,且随着病理分期的提高 ,CD阳性率有逐渐升高趋势。结论 CD的表达与胃癌的分化程度、浆膜侵犯、淋巴结转移相关 ,CD是评估胃癌预后的有效参数
Objective To study the expression of cathepsin D (CD) in gastric cancer and to explore the relationship between CD and biological behavior of gastric cancer. Methods The expression of CD in 50 cases of gastric cancer was detected by S-P immunohistochemistry. The relationship between the expression of CD and clinicopathological factors and clinicopathological stages of gastric cancer was analyzed. Results The positive expression rate of CD was 72% (36/50). The positive expression rate of CD in poorly differentiated group (23/26) was significantly higher than that in differentiated group (13/24) 2) was significantly higher than that of the noninvasive group (16/2 8). The positive lymph node metastasis group (21/2 4) was significantly higher than that of the negative lymph node metastasis group (15/2 6) Rate is gradually rising trend. Conclusion The expression of CD is correlated with the differentiation degree of gastric cancer, serosal invasion and lymph node metastasis. CD is a useful parameter to evaluate the prognosis of gastric cancer