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采用评分法建立了鉴别药物与不良反应之间因果关系相关程度的程序,对心血管病房进行了为期6个月的ADR集中监察。统计了ADR发生率、反应强度、反应类型及反应部位。发现ADR病人的用药种数和住院日期显著多于和长于非ADR病人;药物的特性与病人原发疾病对ADR发生率有明显影响:吡二丙胺、地高辛等引起的ADR发生率较高;严重心衰、心律失常及肾功能不全的病人ADR发生率较高。可鉴药物和疾病可能是两个主要的因素,甚至可掩盖年龄等其它对ADR发生率的影响。
A scoring method was used to establish a procedure for identifying the degree of causation between drugs and adverse reactions and a six-month surveillance of ADR for cardiovascular wards. The incidence of ADR, reaction intensity, reaction type and reaction site were calculated. Found that the number of ADR patients and hospitalization was significantly longer and longer than non-ADR patients; drug characteristics and primary disease patients have a significant impact on the incidence of ADR: dipyridamole, digoxin and other caused by a higher incidence of ADR ; Severe heart failure, arrhythmia and renal insufficiency in patients with a higher incidence of ADR. However, drugs and disease may be the two main factors that may even mask other effects such as age on the incidence of ADR.