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A 38-year-old woman underwent a hysterectomy for a uterine tumor.A giant circumscribed nodule with a diameter of 20 cm at its widest point was found within the myometrium of the uterine corpus without hemorrhage or necrosis. More than 10 specimens were pathologi-cally examined. Eleven years after hysterectomy, she developed five tumors (the largest diameter = 2 cm) in the fight lung and retroperito-heal tumor (the largest diameter = 9.5 cm). Microscopic examination indicated uterine, retroperitoneal and pulmonary foci, which were characterized by a benign appearance, including nodular smooth-muscle proliferation. The smooth muscle cells had an oval shape with relatively clear cytoplasm and a few irregular nuclei.