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目的对高校学生抗结核治疗中出现的不良反应加以分析。方法根据2001~2008年接受抗结核治疗的病例在治疗过程中出现的临床症状及实验室检查异常,分析有关化疗不良反应的类型、发生率。结果接受治疗的106例病例中,共发生不良反应44例,占41.5%,9例为2种或以上不良反应同时发生。其中肝功能异常15例,占14.2%,消化道症状13例,占12.3%,血尿酸升高13例,占12.3%,过敏7例,占6.6%,白细胞减少4例,占3.8%,失眠2例,占1.9%。有16例因肝功能异常和过敏而改变治疗方案。结论抗结核治疗中的不良反应很常见,以肝功能异常、胃肠道症状及尿酸升高尤多,而治疗方案的改变多因肝功能异常和过敏。治疗中应采取个体化方案,严密监测各种不良反应的发生。
Objective To analyze the adverse reactions of anti-TB therapy in college students. Methods According to the clinical symptoms and laboratory abnormalities in the course of treatment of patients receiving anti-TB therapy from 2001 to 2008, the types and incidences of adverse reactions were analyzed. Results Among the 106 cases treated, 44 cases (41.5%) had adverse reactions and two (9) cases had two or more adverse reactions simultaneously. There were 15 cases of abnormal liver function, accounting for 14.2%, 13 cases of gastrointestinal symptoms, accounting for 12.3%, 13 cases of hyperuricemia, accounting for 12.3%, 7 cases accounting for 6.6%, 4 cases of leukopenia accounting for 3.8%, insomnia 2 cases, accounting for 1.9%. There are 16 cases because of liver dysfunction and allergies and change treatment options. Conclusions Adverse reactions in antituberculous therapy are common, with abnormal liver function, gastrointestinal symptoms and elevated uric acid. The treatment regimens are mostly due to abnormal liver function and allergy. Treatment should be individualized programs to closely monitor the occurrence of various adverse reactions.