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目的对比分析甲状腺功能亢进患者采用碘-131和抗甲状腺药物治疗的临床效果。方法选取2013年1月至2015年1月甲状腺功能亢进患者94例,将其随机分为两组,每组47例。对照组采用抗甲状腺药物治疗,观察组采用碘-131治疗,对比两组治疗有效率、治疗前后血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)水平、病情复发率和不良反应情况。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后血清T3、T4下降幅度、TSH上升幅度均优于对照组,差异有统计学意义(P<0.05);观察组病情复发率和不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论甲状腺功能亢进患者采用碘-131治疗效果优于抗甲状腺药物治疗,可明显减少不良反应,降低复发率。
Objective To compare the clinical effects of iodine-131 and anti-thyroid drugs in patients with hyperthyroidism. Methods From January 2013 to January 2015, 94 patients with hyperthyroidism were randomly divided into two groups (n = 47 in each group). The control group was treated with antithyroid drugs. The observation group was treated with iodine-131. The therapeutic efficiency was compared between the two groups before and after treatment. Serum levels of triiodothyronine (T3), thyroid hormone (T4), thyroid stimulating hormone (TSH) Recurrence rate and adverse reactions. Results The therapeutic efficiency of the observation group was higher than that of the control group (P <0.05). The decrease of serum T3 and T4 and the increase of TSH in the observation group were better than those in the control group (P < 0.05). The incidence of recurrence and adverse reactions in the observation group was lower than that in the control group, with significant difference (P <0.05). Conclusions The treatment of iodine-131 in patients with hyperthyroidism is superior to anti-thyroid drugs, which can significantly reduce the adverse reactions and reduce the recurrence rate.