论文部分内容阅读
检测７７例男性肝硬变患者（肝硬变组）和３４例健康男性（对照组）血清甲状腺激素和性激素水平，并采用Ｃｈｉｌｄ－Ｐｕｇｈ分级法将上述病例分为Ａ级（２４例）、Ｂ级（３２例）和Ｃ级（２１例）。结果显示，肝硬变组Ｔ３、Ｔ４明显低于对照组；ｒＴ３明显高于对照组，有显著性差异。肝硬变组Ｃｈｉｌｄ－Ｐｕｓｈ记分与ｒＴ３浓度呈正相关（ｒ＝０．４８，Ｐ＜０．０１），与Ｔ３、Ｔ４浓度无明确相关（Ｐ＞０．０５）。肝硬变组ＦＳＨ，ＬＨ和ＰＲＬ明显高于对照组；Ｔ和Ｅ２明显低于对照组。Ｃｈｉｌｄ－Ｐｕｇｈ记分与Ｔ水平呈负相关（ｒ＝一０．５８，Ｐ＜０．０１），与ＰＲＬ浓度呈正相关（ｒ＝０．３５，Ｐ＜０．０１），与ＦＳＨ，ＬＨ和Ｅ２无明确相关。提示肝功能受损可能是导致肝硬变患者甲状腺激素和性激素异常的重要原因，ｒＴ３、Ｔ和ＰＲＬ对肝硬变患者的预后有一定的指示意义。
Serum levels of thyroid hormones and sex hormones were detected in 77 patients with cirrhosis (cirrhosis group) and 34 healthy men (control group). The patients were divided into grade A (24 cases), B Grade (32 cases) and grade C (21 cases). The results showed that cirrhosis group T3, T4 was significantly lower than the control group; rT3 was significantly higher than the control group, with significant differences. Child-Push scores in cirrhotic patients were positively correlated with rT3 concentrations (r = 0.48, P <0.01), but not with T3 and T4 concentrations (P> 0.05). FSH, LH and PRL in cirrhosis group were significantly higher than those in control group; T and E2 were significantly lower than those in control group. Child-Pugh score was negatively correlated with T level (r = -0.58, P <0.01), positively correlated with PRL concentration (r = 0.35, P <0.01) No clear relevance. Suggesting that impaired liver function may lead to thyroid hormones and sex hormones in patients with cirrhosis is an important cause of abnormal, rT3, T and PRL of cirrhosis patients with prognosis of a certain indication.