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目的:探讨不同程度窒息新生儿肾上腺髓质素活性片段(ADM、ADT)的动态变化及临床意义。方法:抽取正常及窒息新生儿外周静脉血,分离血浆,采用特异性放射免疫分析法检测窒息新生儿150例(其中轻度者84例,重度者66例),正常新生儿80例,生后不同时间血浆ADM,ADT含量。结果:(1)正常新生儿出生1hADM、ADT含量分别为(30.42±4.35)pg/ML,(20.18±3.78)pg/mL,出生48h、5d略有增高但无统计学意义;(2)不同程度窒息新生儿ADM、ADT均较正常儿增高,且重度窒息患儿明显高于轻度窒息患儿,P<0.01;(3)窒息新生儿ADM、ADT在不同时间呈动态变化。ADT以生后48h增高最为显著。结论:窒息新生儿ADM、ADT有显著增高且与病情严重程度呈正相关,可作为新生儿窒息病情演变诊断和治疗的参考指标。
Objective: To investigate the dynamic changes and clinical significance of Adrenomedullin active fragments (ADM, ADT) in neonatal asphyxia. Methods: Peripheral venous blood was collected from normal and asphyxiated neonates and plasma was isolated. 150 neonates with asphyxia (including 84 mild and 66 severe ones) were detected by radioimmunoassay, 80 normal newborns, Plasma ADM, ADT content at different time. Results: (1) The levels of ADT and ADT were (30.42 ± 4.35) pg / mL and (20.18 ± 3.78) pg / mL at 1 hour after birth, respectively. The levels of ADM and ADT in newborns with asphyxia were higher than those in normal children, and the children with severe asphyxia were significantly higher than those with mild asphyxia (P <0.01). (3) The levels of ADM and ADT in asphyxiated newborns at different time showed dynamic changes. ADT increased significantly after 48h after birth. Conclusion: Asphyxia neonates have significantly increased ADM and ADT, which are positively correlated with the severity of the disease, and can be used as a reference for the diagnosis and treatment of neonatal asphyxia.