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对多发性硬化复发的控制是多发性硬化治疗中的一大难题。重组人抗α4整合素单克隆抗体Natalizumab能减少脑部的炎性病灶数及复发次数。研究显示其疗效较 β 干扰素及copolymer Ⅰ更优。此外雌激素、CD3 4+ 选择性自体周围血干细胞移植也为复发性多发性硬化的治疗开辟了新的途径。
Control of multiple sclerosis recurrence is a major problem in the treatment of multiple sclerosis. Recombinant human anti-α4 integrin monoclonal antibody Natalizumab can reduce the number of brain inflammatory lesions and the number of relapses. Studies have shown that its efficacy than β interferon and copolymer Ⅰ better. In addition, estrogen, CD3 4 + selective autologous peripheral blood stem cell transplantation has also opened a new avenue for the treatment of recurrent multiple sclerosis.