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Zollinger和Ellison于1955年报告了两名久治不愈的十二指肠溃疡病人,均有高胃酸和高胃液分泌。后经手术和组织学证实患者患有胰岛非β细胞(D细胞)肿瘤,切除后胃酸分泌下降,溃疡愈合。后来人们称此病为卓—艾氏综合征(ZES),并证实ZES的胰岛D细胞分泌大量的具有强烈刺激酸性胃液分泌的胃泌素,故本病也被称为胃泌素瘤。肿瘤可为恶性或良性,瘤体很小,可多发或单
Zollinger and Ellison reported in 1955 two patients with unresolved duodenal ulcers, both with high gastric acid and high gastric secretion. After surgery and histology, the patient was confirmed to have pancreatic islet non-beta cell (D-cell) tumors. After the resection, gastric acid secretion decreased and ulcers healed. Later, people called the disease Zhuo-Egill’s syndrome (ZES) and confirmed that the islet D cells of ZES secrete a large amount of gastrin that strongly stimulates the secretion of acidic gastric juice, so this disease is also known as gastrinoma. The tumor can be malignant or benign, the tumor is small, can be multiple or single