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目的探讨结肠黑变病的临床、内镜及病理特点。方法回顾分析扬中市中医院和江苏省人民医院2008年6月-2011年8月经结肠镜检查、病理确诊的28例结肠黑变病病例资料。结果结肠镜检查19283例,其中结肠黑变病28例。25例有便秘史,24例有服用蒽醌类药物史。合并结肠息肉5例,未发现癌变。结论结肠黑变病与细胞凋亡有关,便秘及服用药物蒽醌类是细胞凋亡的重要因素。可伴发息肉,早期诊治是预防其进一步发展的有效手段。
Objective To investigate the clinical, endoscopic and pathological features of colonic melanosis. Methods A retrospective analysis of Yangzhong Hospital of Traditional Chinese Medicine and Jiangsu Provincial People’s Hospital from June 2008 to August 2011 by colonoscopy, pathological diagnosis of 28 cases of colorectal disease data. Results Colonoscopy 19,283 cases, including 28 cases of colonic melanosis. 25 cases had history of constipation, 24 cases had taken anthraquinone drug history. Colonic polyps in 5 cases, no cancer was found. Conclusions Colitis mellitus is associated with cell apoptosis. Constipation and administration of anthraquinones are important factors of apoptosis. May be associated with polyps, early diagnosis and treatment is an effective means to prevent its further development.