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目的:探讨二甲双胍、克罗米芬联合治疗多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)合并不孕症的临床疗效情况。方法:根据治疗方案不同将我院80例PCOS合并不孕症患者分为观察组40例(应用二甲双胍、克罗米芬治疗)及对照组40例(应用克罗米芬单药治疗)。治疗3个月经周期后,对比两组激素水平变化情况,并统计患者半年妊娠率。结果:治疗后,观察组促卵泡雌激素、促黄体生成素、睾酮及空腹胰岛素水平均显著低于对照组(P<0.05)。随访发现,观察组半年妊娠率为37.50%,明显高于对照组15.00%(P<0.05)。结论:采用二甲双胍、克罗米芬联合治疗PCOS合并不孕症可有效改善患者激素水平、提高患者妊娠率。
Objective: To investigate the clinical efficacy of metformin and clomiphene in the treatment of polycystic ovarian syndrome (PCOS) with infertility. Methods: 80 cases of PCOS with infertility in our hospital were divided into observation group 40 cases (metformin and clomiphene citrate treatment group) and control group 40 cases (clomiphene citrate single treatment group). After 3 menstrual cycles, the changes of hormone levels were compared between the two groups, and the six-month pregnancy rate was calculated. Results: After treatment, the levels of follicle-stimulating estrogen, luteinizing hormone, testosterone and fasting insulin in the observation group were significantly lower than those in the control group (P <0.05). Follow-up found that the half-year pregnancy rate was 37.50% in observation group, which was significantly higher than that in control group (15.00%, P <0.05). Conclusion: The combination of metformin and clomiphene in treating PCOS combined with infertility can effectively improve the hormone level and improve the pregnancy rate.